Freeze Dryer Technology

Hull Lyophilzers In The News

Avrio has expanded its capacity through the addition of a Hull 72FXS100-SS25C Freeze Drying System.

Pharmaceutical Manufacturing magazine has published an article titled "Low-Risk Lyophilization" which discusses the design and construction of a new cytotoxic / genotoxic production facility. This facility uses Hull lyophilizers with Multi-Flex and SmartCool heat transfer loop control and Variable Frequency Drive (VFD) screw compressors with LN2 backup for refrigeration. The freeze dryers use autolocking chamber doors with sub-doors, autopositioning shelves, and fluid loop condensing.

Hull Lyophilizer Technology Examples

Hull has developed a great understanding of the Pharmaceutical Industry's needs in over 50 years of engineering, fabricating, and assembling standard and custom lyophilization systems. We have worked closely with our customers to manufacture cost-effective, reliable solutions to meet their specific freeze drying requirements. We look forward to working with you.

A Brief Survey of Hull Freeze Dryer Technology

(View our lyophilizer model number syntax below.)

220FXS450-SS25C
Parenteral Production
  • Liquid Nitrogen (LN2)
  • Auto Locking Door
 
360FXS700-SS30C
Veterinary Production
  • Cascade Refrigeration
  • 2-Stage Reciprocating Compressors
  • Auto Locking Door
  • Vertically Oriented Tube-Coil Condenser
 
300FXS450-SS20C
Parenteral Production
  • 2-Stage Reciprocating Compressors
  • Auto Locking Door
  • Smart Cool DX Condenser
 

36FXS50C-SS30C
Research & Development and Pilot Production
  • Temperature Controlled Chamber & Door Jackets
  • Auto Locking Door
  • Hypro Condenser
  • CIP Recirculation System
  • Sampling Thief
  • Clean In Place
  • Steam In Place
 
450FXS800-SS25C
Parenteral Production
  • Screw Compressors
  • Auto Locking Door
  • Sub-door for Autoloading
  • Dual-Loop Brine Heat Transfer
  • Hypro Condenser
  • Clean In Place
  • Steam In Place
 
120FS175-SS25C
Parenteral Production
  • 2-Stage Reciprocating Compressors
  • Tee-handle Door
  • Water Cooled Chamber
  • Water Cooled Door
  • Internal Condenser Plates
  • 2-Story Plant Installation
  • Clean In Place
  • Steam In Place
 

300FXS450-SS25C
Parenteral Production
  • Auto Loading feeds Two Lyophilizers
  • Screw compressors with LN2 Backup
  • Central Brine Heat Transfer
  • Hypro Condenser
  • Clean In Place
  • Steam In Place
 
420FXS800-SS30C
Parenteral Production
  • Screw Compressors
  • Auto Locking Door
  • Water Cooled Chamber
  • Water Cooled Door
  • Vertical Condensers
  • Tube Coil Condensing
  • Recirculating CIP System
  • Clean In Place
  • Steam In Place
 
360FXS450-SS25C
Parenteral Production -Retrofit
  • 2-Stage Reciprocating Compressors
  • Retrofitted 4 shelves (from 280 to 360 Sq.Ft)
  • New Hypro Condenser
  • New Control Package
 

How to read a Hull Freeze Dryer Model Number

Example: 650 F X S 1100 - SS 25C

The 650 indicates the usable shelf product area in square feet. We have made freeze dryers from 2 ft^2 (.19 m^2) to 1080 ft^2 (100 m^2). So far.

The F refers to a freeze dryer as opposed to a shelf dryer. We also make shelf dryers.

The X indicates a freeze dryer with an external ice condenser. We make both internal and external ice condensing systems.

The S refers to a freeze dryer with shelf stoppering capability. We also make freeze dryers with fixed shelves. Our standard stoppering pressure is adjustable to 10 lbf/in^2 (7031 kg/m^2); our highest has been 40 lbf/in^2 (28123 kg/m^2). So far.

The 1100 indicates the lyophilizer's ice condensing capacity as liters of water. We have made condensing systems with capacities from 5 liters to 1200 liters. So far.

The SS indicates stainless steel construction of all product contact and cleanroom surfaces.

The 25C indicates an ASME Code Certified pressure rating of 25 lbf/in^2 gauge. Hull designs and fabricates its vessels in-house and is certified to the American Society of Mechanical Engineers Section VIII Division 1 requirements for Unfired Pressure Vessels. Our standard vessels are rated for steam at 20 psig (1.1.38 bar), 25 psig (1.72 bar), or 30 psig (2.07 bar) dependent upon the customer's requirements.

 

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