Exalt is a new technology developed by Genevac
with partners in the field of pharmaceutical small molecule
crystallisation. Exalt enables a wide range of solvents to be evaporated
at the same time, and all at the same slow rate and is used for
polymorph screening and stable form identification. Therefore, DCM and
Toluene can be placed in the same system and evaporated such that both
samples dry at the same time. Exalt may be used for up to 3ml of solvent
within the boiling point of 40ºC to 165ºC – DCM to DMAc. The evaporation
time can be controlled to range from 6 hours to 72 hours, or more, as
required for most solvents in this boiling point range. The system can
deliver polymorphs of a drug at the same time, in a controlled and
Crystals of Ibuprofen produced by Exalt from ethanol (L) and ethyl acetate (R).
Exalt uses a special holder for vials which allows a selection of
baffles to be placed on top of the vial to slow the evaporation rate of
the volatile solvents. Size and number of baffles are selected to be
most restrictive for the most volatile solvents, and least restrictive
to the less volatile solvents. In some cases no baffle is required. The
holder is then placed in a Genevac HT series evaporator which cycles the samples at atmosphere and at a slightly reduced pressure for the duration of the process.
Exalt is being used and/or evaluated by several major Pharmaceutical companies throughout the world.
Documents and Downloads
Novartis Pharmaceuticals feedback on their work with Exalt technology is in this presentation. The presentation is probably best read in conjunction with this review paper which adds detail. For more information, please contact SPScientific or download the Exalt brochure sheet.