What is ControLyo™ Nucleation Technology?
With ControLyo™ Nucleation on Demand Technology for the first time nucleation can be controlled during a freeze drying process both in laboratory and production scale.
The criticality of the freezing step for the overall freeze drying process has been known for long time and several approaches have been applied to control nucleation, e.g. ice-fog, inducing freezing of the solutions from the surface by applying vacuum, or ultra-sound. The drawback of many of the techniques is that they are only suitable in lab scale.
Praxair Inc. introduced a method for controlling nucleation which is commercially available for both, lab and production scale freeze drying: ControLyo™ Nucleation on Demand Technology.
See ControLyo™ Nucleation Technology in Action
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