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FTS Systems
LyoStar Research & Development Tray Freeze Dryer
The LyoStar3 is designed to meet the needs of R&D professionals. Our freeze drying equipment is used for applications ranging from process development for scale-up to product processing for stability studies to formulations work. Models are available in stoppering and bulk configurations.
The LyoStar is an R&D and process development freeze-dryer that provides unmatched process accuracy, reliability and unique ease-of-use features. The LyoStar features RTD-controlled shelf temperature accuracy of +/- 0.5°C or better and vacuum control within 0.1% of set-point. Its robust 5.5 hp cascade refrigeration system enables shelf pull down from ambient to –40°C in less than 25 minutes, and the ultra-reliable scroll compressors feature just 3 moving parts.
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LyoStar3 is available with Praxair ControLyo Nucleation on Demand Technology. To learn how you can control the nucleation step in freeze drying Click Here |
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KEY FEATURES
- SMART Freeze-Dryer Technology helps automate and shorten the development of freeze-drying cycles
- Delivers product information that has previously been unavailable during a cycle - dried layer resistance, heat flow and mass transfer
- Designed to facilitate scale up bu maximizing features in comon with well-designed commercial systems
- Configured with superior instrumentation for complete process information - isolation valve, capacitance manometers, Pirani gauge, 16 thermocouples, Allen Bradley PLC
- Available with 21 CFR Part 11 compliant software and full validation packages
KEY BENEFITS
- Substantially decrease cycle development time and conserves valuable API
- Delivers increased process information such as how different freezing protocols impact cake resistance
- More easily transfer cycles to larger systems
- Maximizes process control, repeatablility
- Meets even the most stringent QA requirements
HOW TO SELECT
To configure a LyoStar II to fit your requirements, select options from each of the groups below. For assistance in determining which option is right for you or to receive a quote please contact a product specialist. We will be glad to discuss the options and their importance and use with you.
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SPECIFICATIONS
| Specification |
| Shelf Temperature Control Range (°C) |
-70 to +60C
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| Lowest Condenser Temperature |
-85C
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| Maximum Condenser Capacity (L) |
30 L
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| Condenser Surface Area (in2 / cm2) |
828 / 5481
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Maximum Ice Condensing Capacity in 24 hours (L)
This specification is based on freeze drying water as possible.
The ability to collect ice is application dependent and your actual rate will most likely be lower |
20
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| Condenser Pull-Down from 20 °C to -75 °C (minutes) |
< 10
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Shelf Pull-Down from 25 °C to -40 °C
(minutes) |
< 25
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| Vacuum Time to 100 Millitorr (minutes) |
< 20
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| Lowest System Vacuum (mT) |
< 10
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| Shelf Surface Temperature Uniformity (°C) |
+/- 0.5C
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| Shelf Configuration |
| Number of Shelves |
Shelf Area
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Shelf Clearance
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Shelf Clearance with Optional Shelf Latching
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Bulk and Stoppering** (ft2 / cm2)
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Bulk and Stoppering** (in / mm)
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1 Shelf Latched (in / mm)
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2 Shelves Latched (in / mm)
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| 1 Shelf |
1.5 / 1394
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9.5 / 241
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| 2 Shelves |
3.1 / 2880
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4.5 / 114
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9.25 / 235
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-
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| 3 Shelves |
4.6 / 4274
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2.8 / 71
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4.25 / 108
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8.5 / 216
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| 4 Shelves |
6.1 / 5667
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2.0 / 51
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2.6 / 66
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4.0 / 102
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| 5 Shelves |
7.6 / 7061
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1.5 / 38
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| Dimensional Data |
| Width (in / cm) |
33 / 84
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| Depth (in / cm) |
43 / 109
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| Height (in / cm) |
78 / 190
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| Approximate Weight (lb / kg) |
1300 / 590
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| Minimum Clearance on All Sides (ft / cm) |
2 / 61
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APPLICATION EXAMPLES
- Formulation development and stability studies
- Cycle optimization and scale-up
- Lyophilization of product with organic solvents in addition to water
- Laboratory research and development and/or small production freeze drying
- Diagnostic kits
- 96 well plates
- Serum bottles and vials
OPTIONAL COMPONENTS
ACCESSORIES
VirTis 96 Well Freeze Drying Systems (pdf)
Freeze-Drying Product Sensors (pdf)
VirTis MVP Probes(pdf)
| LyoStar II Accessories |
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| Model Number |
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Description |
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| VP200 |
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200 liters per minute vacuum pump |
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| Options |
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l |
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| Voltage |
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C |
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208V/60Hz |
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D |
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220V/50Hz |
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| OME-06 |
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Oil mist eliminator for VP100 |
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| FDPS13 |
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Special product sensor, 13mm |
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| FDPS20 |
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Special SS encased product sensor, 20mm |
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| TS-1120 |
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Bulk tray 11" x 20" |
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| TRB-1120 |
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Removable bottom tray 11" x 20" |
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| LYO-LGT |
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WL Gore LyoGuard Trays |
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| LYO-RDT |
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WL Gore LyoGuard R&D Trays |
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| LYO-SE |
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Sample extractor |
| Options |
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l |
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A |
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120V/60Hz |
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Q |
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195-230V/ 50 or 60Hz |
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| LNT-LYOII |
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Auto refilling Liquid Nitrogen Trap |
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| LYO-MA |
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Moisture sensor on chamber |
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| LYO-DTA |
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Desktop computer (Includes mobile cart and 115V UPS) |
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| LYO-DTD |
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Desktop computer (Includes mobile cart and 230V UPS) |
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| LSLP-2.1 |
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Shelf latching kit for LYO2, 1 shelf up |
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| LSLP-3.1 |
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Shelf latching kit for LYO3, 1 shelf up |
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| LSLP-3.2 |
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Shelf latching kit for LYO3, 2 shelves up |
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| LSLP-4.1 |
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Shelf latching kit for LYO4, 1 shelf up |
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| LSLP-4.2 |
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Shelf latching kit for LYO4, 2 shelves up |
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| LSLP-4.3 |
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Shelf latching kit for LYO4, 3 shelves up |
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| IQ/OQ-LYO |
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Installation Qualification/Operation Qualification documentation. Includes MSDS, component serial numbers and calibration certificates, refrigeration and wiring diagrams, QC test data, acceptance criteria and suggested OQ protocols |
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| SMART Freeze Dryer Technology Option |
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| SMART Freeze Dryer Technology Upgrade |
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Does not include field retrofit charge |
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| Transformers |
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| Model Number |
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Description |
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| TX-50 |
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Transformer, step down, 50A |
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| TX-50-SU |
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Transformer, step up, 50A |
LITERATURE & ADDITIONAL SPECIFICATIONS
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