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FTS Systems
SMART Freeze Drying
SMART Freeze-Dryer Technology is a patented system that puts the experience of the world’s top lyophilization scientists into an easy-to-use cycle development tool. Developed exclusively with leading academics at The University of Connecticut and Purdue University, this technology is available on the LyoStar freeze-dryer (including a retrofit option for existing LyoStar II systems).
SMART Freeze-Dryer technology eliminates the trial-and-error approach normally involved in developing new lyophilization cycles. It enables experts and novices alike to develop new cycles quickly, while also ensuring that those cycles are elegant and efficient.
The SMART tools provide instant feedback on important product data — such as product resistance, heat flow, and mass transfer — that was previously unavailable.
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KEY FEATURES
- SMART Freeze Dryer Technology (PLC) helps automate and shorten the development of the freeze drying cycle
- Get product information that has previously been unavailable – such as product resistance, heat flow and mass transfer
- Designed to minimize issues with transfer of freeze drying cycles to your production freeze dryer
- Easy to use operator interface
- Condenser coil type configuration to maximize condenser efficiency
- Available with optional 21 CFR Part 11
- Clean room configurations available
KEY BENEFITS
- Substantially decrease cycle development time with SMART
- Understand more about your product and its obstacles and opportunities in lyophilization cycle development
- Easily transfer cycles to larger systems
- Increase ROI with greater throughput and optimized cycles
- Spend more time looking at formulation strategies to maximize product effectiveness
- Developed by lyophilization scientists for lyophilization scientists
HOW TO SELECT
To configure a LyoStar II with SMART Freeze Dryer Technology to fit your requirements, select options from each of the groups below. For assistance in determining which option is right for you or to receive a quote, please contact a product specialist. We will be glad to discuss with you the options and their importance and use.
SPECIFICATIONS
| Specification |
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| Shelf Temperature Control Range (°C) |
-70 to +60C
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| Lowest Condenser Temperature |
-85C
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| Maximum Condenser Capacity (L) |
30 L
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| Condenser Surface Area (in2 / cm2) |
828 / 5481
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Maximum Ice Condensing Capacity in 24 hours (L)
This specification is based on freeze drying water as aggessively as possible.
The ability to collect ice is application dependent and your actual rate will most likely be lower |
20
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| Condenser Pull-Down from 20 °C to -75 °C (minutes) |
< 10
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Shelf Pull-Down from 20 °C to -40 °C
(minutes) |
< 25
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| Vacuum Time to 100 Millitorr (minutes) |
< 20
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| Lowest System Vacuum (mT) |
< 10
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| Temperature Uniformity (°C)\\ |
+/- 1.0C
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| Shelf Configuration |
| Number of Shelves |
Shelf Area
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Shelf Clearance
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Shelf Clearance with Optional Shelf Latching
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Bulk and Stoppering** (ft2 / cm2)
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Bulk and Stoppering** (in / mm)
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1 Shelf Latched (in / mm)
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2 Shelves Latched (in / mm)
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| 1 Shelf |
1.5 / 1394
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9.5 / 241
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| 2 Shelves |
3.1 / 2880
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4.5 / 114
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9.25 / 235
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| 3 Shelves |
4.6 / 4274
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2.8 / 71
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4.25 / 108
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8.5 / 216
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| 4 Shelves |
6.1 / 5667
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2.0 / 51
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2.6 / 66
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4.0 / 102
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| 5 Shelves |
7.6 / 7061
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1.5 / 38
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| Dimensional Data |
| Width (in / cm) |
33 / 84
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| Depth (in / cm) |
43 / 109
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| Height (in / cm) |
75 / 190
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| Approximate Weight (lb / kg) |
1300 / 590
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| Minimum Clearance on All Sides (ft / cm) |
2 / 61
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APPLICATION EXAMPLES
- Laboratory research and development and/or small production freeze drying
- Process development with intent to move process to clinical size freeze dryer
- Serum bottles and vials
OPTIONAL COMPONENTS
ACCESSORIES
VirTis 96 Well Freeze Drying Systems (pdf)
Freeze-Drying Product Sensors (pdf)
| yoStar II Accessories |
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| Model Number |
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Description |
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| VP200 |
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200 liters per minute vacuum pump |
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| Options |
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l |
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| Voltage |
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C |
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208V/60Hz |
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D |
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220V/50Hz |
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| OME-06 |
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Oil mist eliminator for VP100 |
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| FDPS13 |
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Special product sensor, 13mm |
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| FDPS20 |
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Special SS encased product sensor, 20mm |
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| TS-1120 |
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Bulk tray 11" x 20" |
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| TRB-1120 |
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Removable bottom tray 11" x 20" |
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| LYO-LGT |
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WL Gore LyoGuard Trays |
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| LYO-RDT |
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WL Gore LyoGuard R&D Trays |
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| LYO-SE |
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Sample extractor |
| Options |
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A |
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120V/60Hz |
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Q |
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195-230V/ 50 or 60Hz |
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| LNT-LYOII |
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Auto refilling Liquid Nitrogen Trap |
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| LYO-MA |
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Moisture sensor on chamber |
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| LYO-DTA |
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Desktop computer (Includes mobile cart and 115V UPS) |
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| LYO-DTD |
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Desktop computer (Includes mobile cart and 230V UPS) |
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| LSLP-2.1 |
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Shelf latching kit for LYO2, 1 shelf up |
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| LSLP-3.1 |
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Shelf latching kit for LYO3, 1 shelf up |
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| LSLP-3.2 |
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Shelf latching kit for LYO3, 2 shelves up |
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| LSLP-4.1 |
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Shelf latching kit for LYO4, 1 shelf up |
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| LSLP-4.2 |
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Shelf latching kit for LYO4, 2 shelves up |
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| LSLP-4.3 |
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Shelf latching kit for LYO4, 3 shelves up |
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| IQ/OQ-LYO |
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Installation Qualification/Operation Qualification documentation. Includes MSDS, component serial numbers and calibration certificates, refrigeration and wiring diagrams, QC test data, acceptance criteria and suggested OQ protocols |
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| SMART Freeze Dryer Technology Option |
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| SMART Freeze Dryer Technology Upgrade |
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Does not include field retrofit charge |
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| Transformers |
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Description |
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| TX-50 |
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Transformer, step down, 50A |
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| TX-50-SU |
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Transformer, step up, 50A |
LITERATURE & ADDITIONAL SPECIFICATIONS
Literature
LyoStar 3 Specifications
LyoS_Overview ppt
LyoStar II - Brochure (pdf)
LyoStar II - Specifications (pdf)
Articles of Interest on SMART Freeze DryingTM Technology
Freeze Drying Heat & Mass Transfer: Factors in Dry Cake Resistance by Manometric Temperature Measurement (MTM) - Tank, Nail, Pikal - AAPS Biotech 2005(pdf)
Collapse Measurement by FD Microscopy... Influence of Solute Concentration on Collapse Behavior & Effect on Cycle Design - Meister, Ellnain, Gieseler(pdf)
Design of Freeze-Drying Process for Pharmaceuticals: Practical Advice - Tang, Pikal(pdf)
Effect of Concentration, Vial Size & Fill Depth on the Product Resistance of Sucrose...- Schneid, Gieseler - PittCon 2007(pdf)
PAT-for-Freeze-Drying-Cycle-optimization-in-the-laboratory---Gieseler (pdf)
SMART Freeze-Drying Technology: Impact of Water Readsorption of PVP in MTM - Gieseler, Mather, Pikal(pdf)
SMART Freeze- Drying - Sesholtz, Mather(pdf)
Entwichlung von Lyophilisationszyklen ohne aufwendige Vorversuche - Mather(pdf)
Suppression de la methode par essais et ereurs dans le developpement des cycles de lyophilisation.(pdf)
Eliminando las aproximaciones sucesivas de los chiclos de liofilizacion en desarrollo (pdf)
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Send to a Colleague
Your message (click here):
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Presenter: Mark Shon
Importance of Controlling Nucleation Temperature During the Freeze Step
23 Feb 2012
9 AM & 2 PM ET
Register Now
Instructor: Dr. Jeff Schwegman
Lyophilization Cycle Development & Optimization:
A Hands On Laboratory Course
Two 2012
Sessions Added!
June 5-8, 2012
Oct 23-26, 2012
Learn More
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