LyoStar 3

The LyoStar3 is designed to meet the needs of R&D professionals. Our freeze drying equipment is used for applications ranging from process development for scale-up to product processing for stability studies to formulations work.

The LyoStar is an R&D and process development freeze-dryer that provides unmatched process accuracy, reliability and unique ease-of-use features. The LyoStar features Type T thermocouple-controlled shelf temperature accuracy of +/- 0.5°C or better and vacuum control within 0.1% of set-point. Its robust 5.5 hp cascade refrigeration system enables shelf pull down from ambient to –40°C in less than 25 minutes, and the ultra-reliable scroll compressors feature just 3 moving parts.  

LyoStar3 is available with ControLyo™ Nucleation Technology.  To learn how you can control the nucleation step in freeze drying view our webinars and articles and technical papers on ControLyo Technology.

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Key Features

  • SMART Freeze-Dryer Technology helps automate and shorten the development of freeze-drying cycles
  • Delivers product information that has previously been unavailable during a cycle - dried layer resistance, heat flow and mass transfer
  • Designed to facilitate scale up by maximizing features in common with well-designed commercial systems
  • Configured with superior instrumentation for complete process information - isolation valve, capacitance manometers, Pirani gauge, 16 thermocouples, Allen Bradley PLC
  • Available with 21 CFR Part 11 compliant software and full validation packages

Key Benefits

  • Substantially decrease cycle development time and conserves valuable API
  • Delivers increased process information such as how different freezing protocols impact cake resistance
  • More easily transfer cycles to larger systems
  • Maximizes process control, repeatablility
  • Meets even the most stringent QA requirements
Specification
Shelf Temperature Control Range (°C)
-70 to +60C
Lowest Condenser Temperature
-85C
Maximum Condenser Capacity (L)
30 L
Condenser Surface Area (in2 / cm2)
828 / 5481
Condenser Pull-Down from 20 °C to -75 °C (minutes)
< 10
Shelf Pull-Down from 25 °C to -40 °C
(minutes)
< 25
Vacuum Time to 100 Millitorr (minutes)
< 20
Lowest System Vacuum (mT)
< 10
Shelf Surface Temperature Uniformity (°C)
+/- 0.5C

 

Shelf Configuration
Number of Shelves
Shelf Area
Shelf Clearance
Shelf Clearance with Shelf Latching
 
Stoppering** (ft2 / cm2)
Stoppering** (in / mm)
1 Shelf Latched (in / mm)
2 Shelves Latched (in / mm)
1 Shelf
1.5 / 1394
9.5 / 241
-
-
2 Shelves
3.1 / 2880
4.5 / 114
9.25 / 235
-
3 Shelves
4.6 / 4274
2.8 / 71
4.25 / 108
8.5 / 216
4 Shelves
6.1 / 5667
2.0 / 51
2.6 / 66
4.0 / 102

 

Dimensional Data
Width (in / cm)
33 / 84
Depth (in / cm)
43 / 109
Height (in / cm)
78 / 190
Approximate Weight (lb / kg)
1300 / 590
Minimum Clearance on All Sides (ft / cm)
2 / 61
  • Formulation development and stability studies
  • Cycle optimization and scale-up
  • Lyophilization of product with organic solvents in addition to water
  • Laboratory research and development and/or small production freeze drying
  • Diagnostic kits
  • 96 well plates
  • Serum bottles and vials

 LyoStar 3 Brochure (eBook)   (View in PDF)

 LyoStar 3 Specifications (pdf)

 Freeze Dryer Overview Brochure - English (pdf)  |  Chinese (pdf)   |  French (pdf)German (pdf)  |  Mandarin (pdf)   |  Portuguese (pdf)  |  Spanish (pdf)