Free online seminar series with topics of interest to lyophilization scientists and presented by industry experts.
Live sessions allow participants to interact with renowned freeze-drying specialists, such as Dr. John Carpenter, Dr. Steve Nail, Dr. Michael Pikal, and other who's who of the freeze-drying community.
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High Resolution Methods for Characterizing Lyophilized Protein Formulations
Date & Time: 7/28/2015 9:00 AM - 3:00 PM ET
Presenter(s): Liz Topp, Ph.D
talk will focus on the recent results from the Department of Industrial and Physical Pharmacy group at
Purdue University for equine myoglobin (Mb).
Over the last decade, the Department of Industrial and Physical Pharmacy group at
Purdue University developed
solid-state hydrogen deuterium exchange (ssHDX-MS) and photolytic labeling
(ssPL-MS) with mass spectrometric analysis to probe protein conformation and
matrix interactions in lyophilized solids with peptide-level resolution. This
talk will focus on their recent results for equine myoglobin (Mb). ssHDX-MS
results demonstrate a strong correlation between Mb aggregation during one year
of storage in the solid state and deuterium uptake immediately following
lyophilization. ssPL-MS allows one to explore the immediate environment of
protein side chains in the solid state. The methods show promise as tools for
screening lyophilized formulations and processing conditions.