Exalt Controlled Crystallisation

Exalt is a new technology developed by Genevac with partners in the field of pharmaceutical small molecule crystallisation. Exalt enables a wide range of solvents to be evaporated at the same time, and all at the same slow rate and is used for polymorph screening and stable form identification. Therefore, DCM and Toluene can be placed in the same system and evaporated such that both samples dry at the same time. Exalt may be used for up to 3ml of solvent within the boiling point of 40ºC to 165ºC – DCM to DMAc. The evaporation time can be controlled to range from 6 hours to 72 hours, or more, as required for most solvents in this boiling point range. The system can deliver polymorphs of a drug at the same time, in a controlled and reproducible way

Crystals of Ibuprofen produced by Exalt from ethanol (L) and ethyl acetate (R).

Crystals

Holder

Exalt uses a special holder for vials which allows a selection of baffles to be placed on top of the vial to slow the evaporation rate of the volatile solvents. Size and number of baffles are selected to be most restrictive for the most volatile solvents, and least restrictive to the less volatile solvents. In some cases no baffle is required. The holder is then placed in a Genevac HT series evaporator which cycles the samples at atmosphere and at a slightly reduced pressure for the duration of the process.

Exalt is being used and/or evaluated by several major Pharmaceutical companies throughout the world.

Documents and Downloads

Novartis Pharmaceuticals feedback on their work with Exalt technology is in this presentation. The presentation is probably best read in conjunction with this review paper which adds detail. For more information, please contact SPScientific or download the Exalt brochure sheet.

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