SP Hull LyoCapsule Freeze Dryer

The LyoCapsule™ Freeze Dryer simulates large R&D freeze dryers so you can screen formulations for freeze drying feasibility, understand critical product attributes and define product and process design space even with limited/expensive materials.
LyoCapsule’s small freeze drying chamber has a cylindrical inner chamber and utilizes wall temperature control to assure that edge vials dry under the same conditions as the center vial.

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  • LyoCapsule


  • Operator at LyoCapsule FD

    Operator at LyoCapsule FD

  • LyoCapsule Chamber

    LyoCapsule Chamber

  • 7 Vial Chamber

    7 Vial Chamber

  • TDLAS Access Door

    TDLAS Access Door

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Key Features:

  • Unmatched process accuracy and reliability
  • Sophisticated instrumentation set 
  • Advanced cycle development and optimization feature 
  • Reliable hermetic compressors
  • Equipped with LyoS™ software
  • Controlled wall temperature to emulate other freeze dryer operating conditions
  • Great for small amount of API or high value API
  • Use to screen formulations

Key Benefits:

  • Accommodates up to seven (7) 20cc vials;
  • Can process 2 cc to 20 cc vials
  • Screen formulations for freeze drying feasibility without the use of large quantities of API
  • Determination of process robustness
  • Ensure that critical formulation collapse temperature is not exceeded during primary drying
  • Define proper shelf temperature and pressure selection for effective sublimation process
  • Plan process scale-up and troubleshoot issues often encountered in large commercial freeze dryers
  • High value and small quantity API
  • Biosimilars
  • ADC’s
  • Proteins

System Overview

  • CFC free refrigerant
  • Allen Bradley PLC controller
  • Pirani/Capacitance Manometer and Barometric Endpoint control software
  • Auto backfill and stoppering
  • Desktop computer with SP Scientific LyoS™ software for ease of use
  • Equipped with SMART™ Freeze Drying Technology*; TDLAS compatible