Powerful Software Utility for Modelling Freeze Drying Cycles

Powerful Software Utility for Modelling Freeze Drying Cycles

Release Date: July 11, 2016

SP Scientific announces the introduction of the LyoModelling Calculator (LMC) - a powerful new software utility that enables those developing freeze drying cycles to calculate the time required for primary drying and the maximum product temperature based on user data input.

This free software resource is available in the LyoTools section of the website. Users obtain a starting point for primary drying duration and the maximum product temperature at the sublimation interface using pertinent information, such as shelf temperature and chamber pressure, from which an optimized freeze-drying cycle can be developed. The LMC is based on the steady-state heat and mass transfer model of primary drying developed by Dr. Michael Pikal with modifications by Dr. Robin Bogner and Royce Labriola at the University of Connecticut (USA).

The LyoModelling Calculator was developed for aqueous product in vials in direct contact with the shelves in a lyophilizer. Primary drying phase is a very important phase and typically the longest phase during the lyophilization process. Careful design of the primary drying phase is critical to ensure critical product temperature is not compromised during the sublimation process which could impact the final product quality attributes. The calculation is intended to be an estimate only, to be used to explore and compare the effects of combinations of freeze-drying parameters on primary drying time and understanding the product temperature dynamics during the primary drying process.

To encourage interested scientists and engineers to learn more about what the LyoModelling Calculator can incorporate in their development approach, SP Scientific has organized 2 free online webinars. The first webinar – ‘LyoModelling Calculator - A New Tool to Assist in Freeze-Drying ProcessDesign
provides an informative introduction to this exciting new software tool.  The second webinar – ‘LyoModelling Calculatorfor Advanced Users - New Cycle Modelling Tooloffers experienced freeze drying users an informative guide through more in-depth functions of the LyoModelling Calculator.
For further information on the LyoModelling Calculator please visit
or contact SP Scientific at +1-845-255-5000 / Shireen.scott@spscientific.com.

Service Contact Information

For SP Service & Support Enquiries - Including Spare Parts

Email: service@spscientific.com

For SP Customer Service Enquiries

Email: csg@spscientific.com

Featured Product

LyoConstellation S30 Freeze Dryer
LyoConstellation Development & Pilot Freeze Dryers

LyoModelling Calculator

LMC Icon

New LyoTool to 

model a freeze-drying cycle 

Request a Quote

Interested in learning more about our products?

Our Lyo Tools

LyoTools Circles


Our Lyo Tools include the Dictionary, the Conversion Calculator and the Vapor Pressure Chart.

"The technical information on your website, and the free lyo seminars you offer are a testament to your expertise.  The resources are truly invaluable and appreciated."

Actual Client Testimonial


About Our Trusted Brands