Freeze Drying Monitoring & Control

Freeze Drying Monitoring & Control

Release Date: September 11, 2014

SP Scientific has entered into an exclusive agreement with Physical Sciences Inc. (PSI) to distribute the LyoFlux® 200 Water Vapor Mass Flow Rate Monitor for laboratory and pilot scale freeze dryers.  The LyoFlux® 200 is an innovative two line-of-sight tuneable diode laser absorption spectroscopy (TDLAS) based device for continuous monitoring of laboratory, pilot and production scale lyophilization cycles.


Operating in conjunction with SP Scientific’s LyoStar 3 development freeze dryer the LyoFlux® 200 enables users to better understand instantaneous changes in water vapor mass flow, and thus the sublimation rate for a given product during freeze-drying. This is of particular importance for products processed in atypical container systems including syringes and PCR microplates.

The LyoFlux® 200 has also been shown to provide highly sensitive end point determination for both primary and secondary drying; continuous mass balance determination; real-time calculation of average product temperature and resistance as well as assessment of heat transfer coefficients for vials (Kv) or other containers. The LyoFlux® 200 can be used for performance testing and design space calculations on a freeze dryer.

Compact in design the LyoFlux® 200 can be installed and utilized on all sizes of developmental freeze dryers. For further information please contact SP Scientific on +1-845-255-5000 or
shireen.scott@spscientific.com

Physical Sciences Inc. is located in Andover, MA, USA, and provides contract research and development services in a wide diversity of technical areas to both government and commercial customers.  Interests span basic research to technology development, with an emphasis on applied research.


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