Understanding How Controlled Nucleation Temperature Impacts Product Resistance

Understanding How Controlled Nucleation Temperature Impacts Product Resistance

Release Date: May 21, 2012

SP Scientific has written a new technical article that describes research undertaken to understand the impact of controlled nucleation temperature on freeze drying product resistance. The researchers demonstrate how SMART™ Freeze Dryer technology is able to simplify and accelerate the determination of product resistance during controlled nucleation freeze drying experiments.

SMART Freeze Dryer technology is a unique control software tool proven to enable development scientists to accelerate and streamline the arduous task of developing and optimizing freeze drying cycles.  Based upon unique control algorithms developed by some of the world's leading lyophilisation experts - SMART Freeze Dryer Technology enhances freeze dry cycle development in several important ways.  Traditional cycle development relies on the experience and intuition of the development scientist, along with a trial and error approach. This often requires weeks of development time, and multiple test cycles can consume scarce and valuable active ingredients. SMART technology enables the developer to generate the right cycle on the first attempt. 

The authors of the technical article demonstrate how SMART Freeze Dryer technology is able, in conjunction with ControLyo On-Demand Nucleation Technology, to instantly link product related properties such as product resistance to important process performance attributes. ControLyo and SMART technologies are exclusively available on the SP Scientific Lyostar 3 research & development freeze dryer.

View a copy of "Optimization of Primary Drying Time Using a Combination of ControLyo™ Nucleation on Demand and SMART™ Freeze Dryer Technology" in the Tech Brief section of the website.

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