New Tool for Monitoring Pharmaceutical Freeze Drying

 New Tool for Monitoring Pharmaceutical Freeze Drying

Release Date: December 03, 2014

A New Tool for Monitoring Pharmaceutical Freeze Drying

SP Scientific has published a new white paper that examines the benefits of applying Tunable Diode Laser Absorption Spectroscopy (TDLAS) for monitoring of pharmaceutical freeze drying processes.

Written by William J. Kessler,
Principal Research Scientist at Physical Sciences Inc., this paper discusses how through the combination of TDLAS Near-IR spectroscopic measurements and a well-established heat and mass transfer model describing freeze drying, users can obtain information about key process parameters affecting end product quality. 

The white paper provides an informative introduction to the physics behind the TDLAS principle of operation.  The authors also describe the application of the technique, using the SP Scientific LyoFlux 200 LyoFlux sensor, to primary and secondary freeze drying endpoint and product temperature determinations. In addition to the determination of process endpoints and product temperatures, the LyoFlux 200 TDLAS sensor can be used to assess freeze dryer equipment capability limits, monitor process and product parameters and also for developing drying cycles based upon Quality by Design procedures.

In summary, the white paper shows how the LyoFlux 200 TDLAS sensor provides a unique measurement capability that provides autonomous and continuous water vapor mass flow determinations throughout the freeze drying process.  LyoFlux is therefore applicable to laboratory, pilot and production scale freeze dryers, enabling use of this PAT tool for process scale-up and process control.

To download a copy of this white paper please visit For further information on the LyoFlux 200 please contact SP Scientific on +1-845-255-5000 or email

Service Contact Information

For SP Service & Support Enquiries - Including Spare Parts


For SP Customer Service Enquiries


Featured Product

LyoConstellation S30 Freeze Dryer
LyoConstellation Development & Pilot Freeze Dryers

LyoModelling Calculator

LMC Icon

New LyoTool to 

model a freeze-drying cycle 

Request a Quote

Interested in learning more about our products?

Our Lyo Tools

LyoTools Circles


Our Lyo Tools include the Dictionary, the Conversion Calculator and the Vapor Pressure Chart.

"The technical information on your website, and the free lyo seminars you offer are a testament to your expertise.  The resources are truly invaluable and appreciated."

Actual Client Testimonial


About Our Trusted Brands