SP Hull Production Freeze Dryer / Lyophilizer

Hull designs, manufactures, installs, and services cGMP vacuum freeze drying equipment for the reliable lyophilization of a wide range of pharmaceutical and biotech products. We have a broad line of standard freeze dryer models and ancilliary equipment such as Clean-In-Place skids and autoloading and unloading systems. We also provide highly customized equipment upon request, utilizing fifty-plus years of industry experience and our in-house engineering and fabrication resources.

Hull offers full System Integration and Factory Acceptance testing, and IQ, OQ, and SIT documentation packages using the GAMP 5 model. Installation services and after-sale technical service and replacement parts are also available.

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  • Hull Production Freeze Dryer / Lyophilizer

    Hull Production Freeze Dryer / Lyophilizer

  • Hull Production Freeze Dryer

    Hull Production Freeze Dryer

  • Hull Production Lyophilizer

    Hull Production Lyophilizer

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Standard Features

  • 25 PSIG ASME Code Pressure Vessel Rating
  • Automatic Perimeter Locking Door
  • Heavy-Duty Shelf Construction (Maintains flatness for the life of the system)
  • Double Latching
  • Stainless Steel Stoppering Ram Bellows
  • Smart Cool 4.0 Electronic Refrigeration Control
  • Lyo-Link is 21 CFR 11 Configurable PC/PLC based Control System

Standard Freeze Dryer Options


Refrigeration with Smart Cool®
• Reciprocating Compressors
• Screw Compressors
• LN2 Refrigeration
• Cascade Refrigeration

Heat Transfer
• Direct Expansion Condensing
• Flooded Loop Condensing
• Internal Condensing
• External and Hypro® Condensing

• Rotary Vane Vacuum Pumps
• Rotary Piston Vacuum Pumps
• Mechanical Booster Vacuum Pumps
• Liquid Ring Vacuum Pumps
• Dry Screw Pumps

• Clean-in-Place
• Steam-in-Place
• Vaporous Hydrogen Peroxide

• Auto-locking doors
• Sub-doors
• Pass-through
• Semi-Manual Loaders & Unloaders
• Automatic Loading & Unloading
• GAMP 4
• 21 CFR 210
• 21 CFR 211
• ASME Sect. VIII Div. 1 Pressure Vessels
• Seismic Certification

• Borescope Maps
• Materials Certifications
• System Integration Testing
• Factory Acceptance Testing
• Installation Qualification
• Operational Qualification

Retrofit Options
• Controls Upgrades
• Refrigeration Upgrades
• Product Shelves
• Process Vessels
• Vacuum Upgrades
• Clean-In-Place Retrofits
• ControLyo Nucleation On Demand Technology

Service Options
• Installation
• Startup
• Training
• Validation Assistance
• Preventative Maintenance


Hull excels at custom lyophilization systems:Request Your Custom Freeze Dryer Quote

Complete installation, startup, and training services are available to help you bring your lyophilization suite online quickly. We also provide preventative maintenance contracts and service and parts support to help you maintain your lyophilizer at optimum efficiency.


Lyophilizer Selection Guide

These freeze dryers are only our starting points - we will be glad to use our 50-plus years of experience to custom engineer a freeze dryer to your exact requirements.

Click on a model number to view the specification sheet. (Learn how to read a Hull Freeze Dryer Model Number)

ModelShelf Size
W x D inch (mm)
Product Area
sq.ft (sq.m)
Ice Capacity
24FS4024 x 36 (610 x 914)24 (2.23)40 - internal
24FXS5024 x 36 (610 x 914)24 (2.23)50 - external
48FS7524 x 36 (610 x 914)48 (4.46)75 - internal
48FXS7524 x 36 (610 x 914)48 (4.46)75 - external
72FS10036 x 48 (914 x 1219)72 (6.69)100 - internal
72FXS10036 x 48 (914 x 1219)72 (6.69)100 - external
120FS17536 x 48 (914 x 1219)120 (11.15)175 - internal
120FXS20036 x 48 (914 x 1219)120 (11.15)200 - external
220FXS45048 x 60 (1219 x 1524)220 (20.44)450 - external
450FXS80060 x 72 (1524 x 1829)450 (41.81)800 - external


How to read a Hull Freeze Dryer Model Number


Example: 650 F X S 1100 - SS 25C


 The 650 indicates the usable shelf product area in square feet. We have made freeze dryers from 2 ft22 (.19 m22) to 1080 ft22 (100 m22). So far.

The F refers to a freeze dryer as opposed to a shelf dryer. We also make shelf dryers.

The X indicates a freeze dryer with an external ice condenser. We make both internal and external ice condensing systems.

The S refers to a freeze dryer with shelf stoppering capability. We also make freeze dryers with fixed shelves. Our standard stoppering pressure is adjustable to 10 lbf/in22 (7031 kg/m22); our highest has been 40 lbf/in22 (28123 kg/m22). So far.

The 1100 indicates the lyophilizer's ice condensing capacity as liters of water. We have made condensing systems with capacities from 5 liters to 1200 liters. So far.

The SS indicates stainless steel construction of all product contact and cleanroom surfaces.

The 25C indicates an ASME Code Certified pressure rating of 25 lbf/in2 gauge. Hull designs and fabricates its vessels in-house and is certified to the American Society of Mechanical Engineers Section VIII Division 1 requirements for Unfired Pressure Vessels. Our standard vessels are rated for steam at 20 psig (1.1.38 bar), 25 psig (1.72 bar), or 30 psig (2.07 bar) dependent upon the customer's requirements.



    • Vaccines
    • Biotherapuetics
    • Oncology Products
    • Wound care products


      • Pass-Through Double Door Design
      • Automatic Clean-In-Place
      • Chamber Wall Temperature Control
      • Liquid Nitrogen Assist or Back-up
      • Additional Shelves
      • Rotary Disk Isolation Valve
      • Automatic Loading and Unloading
      • Vial Transfer Systems
      • Clean In Place Skids
      • Restricted Access Barrier Systems
      • Integrated Filter Integrity Testing
      • Performance Enhancements
      • Customized Equipment Layouts