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Phase Transformations During Freeze-Drying: Potential Implications on Drug Product Performance

Occured: 12/12/2017 10:00 AM - 2:00 PM ET Presenter(s): Raj Suryanarayanan, Ph.D
Four case studies will be presented and will deal with: (i) crystallization of the widely used lyoprotectant, trehalose,  (ii) controlling the physical form of mannitol crystallizing from solution during cooling, (iii) in situ salt formation during freeze-drying and (iv) salt disproportionation during freeze-drying due to pH shift in frozen solutions. In each case, the potential implications on product performance will be discussed.

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