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View recent webinars on "Techniques for Enhancing Visualization of Lyophilization Cakes"; the three-part series on "Lyophilization Validation: Operational Qualification and Process Validation"; learn the "Basic Theory of Freeze Drying" and much more...

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LyoLearn Webinars

Webinar Tech Notes

Webinars

Free online seminar series with topics of interest to lyophilization scientists and presented by industry experts.

Live sessions allow participants to interact with renowned freeze-drying specialists such as Dr. John Carpenter, Dr. Steve Nail and others in the freeze-drying community.

PLEASE NOTE: You must login before you can register or attend a webinar. Live webinars will be enabled 15 minutes prior to the start of each session.

Technical Difficulties? Email Audrey Brand or call +1-845-255-5000 x2381

PLEASE CHECK CONFIRMATION EMAIL iCAL WEBINAR TIMES - TIMES LISTED BELOW ARE CORRECT.

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Upcoming Sessions

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Predictive Models of Lyophilization Process for Development, Scale-up, Technology Transfer, and Manufacturing
Date & Time: 7/30/2019 10:00 AM - 4:00 PM ET Presenter(s): Ehab Moussa, Ph.D.
View Abstract
- Session 1
  
  7/30/2019 10:00 AM - 11:00 AM ET
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- Session 2
  
  7/30/2019 3:00 PM - 4:00 PM ET
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Scale-up and technology transfer of lyophilization processes are challenges that require thorough characterization of the laboratory and larger scale lyophilizers. See abstract for more information.

Scale-up and technology transfer of lyophilization processes are challenges that require thorough characterization of the laboratory and larger scale lyophilizers. In this work, computational fluid dynamics and steady state heat and mass transfer modeling of the vial were utilized for scale-up and technology transfer. The models were verified experimentally for lyophilizers of different scales, and were then applied to create and evaluate a design space for a drug product.

DISCLOSURES
Ehab Moussa is an employee of AbbVie and may own AbbVie stock. AbbVie sponsored and funded the study; contributed to the design; participated in the collection, analysis, and interpretation of data, and in writing, reviewing, and approval of the final publication.
Using Solid-State NMR Spectroscopy as a Tool for Developing Stable Lyophilized Protein Formulations
Date & Time: 8/27/2019 10:00 AM - 3:00 PM ET Presenter(s): Ashley Lay-Fortenbery
View Abstract
- Session 1
  
  8/27/2019 10:00 AM - 11:00 AM ET
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- Session 2
  
  8/27/2019 2:00 PM - 3:00 PM ET
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This webinar will provide several case studies focusing on the analysis of phase separation and local mobility using SSNMR in formulations containing various proteins and stabilizers. View abstract for more information.

Solid-State Nuclear Magnetic Resonance Spectroscopy (SSNMR) is a powerful analytical tool that can be utilized in order to characterize the lyophilized matrix and predict stability in lyophilized protein formulations. SSNMR can access different length scales and time scales in the solid matrix. Using ¹H T₁and ¹H T_1rho relaxation times, phase separation can be studied on 20-50 nm and 2-5 nm length scales. The ¹H T₁ relaxation time can also access the ps-ns timescale, which provides information on the local mobility within the cake matrix. This webinar will provide several case studies focusing on the analysis of phase separation and local mobility using SSNMR in formulations containing various proteins (lysozyme, BSA, and IgG) and stabilizers (sucrose, trehalose, and mannitol). Additionally, a study using SSNMR to study ionization changes in the solid matrix will be presented.
Equipment Capability of Freeze Dryers and Its Relevance to the Graphical Design Space for Primary Drying
Date & Time: 9/26/2019 10:00 AM - 3:00 PM ET Presenter(s): Jayasree Srinivasan, Ph.D.
View Abstract
- Session 1
  
  9/26/2019 10:00 AM - 11:00 AM ET
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- Session 2
  
  9/26/2019 2:00 PM - 3:00 PM ET
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This webinar will discuss how the equipment capability of both laboratory and production freeze-dryers influences the graphical design space for primary drying. View abstract for more information.

The equipment capability curve is one of two boundary conditions employed in the construction of a graphical design space to establish a relationship between process variables and product temperature. Scale-up of processes from laboratory to production equipment can be a challenge if the capability of the equipment is not well understood. In this presentation, we will discuss methods employed to determine the capability of both laboratory and production freeze-dryers and a comparison between to the two to determine their functional equivalencies. We will also discuss how the equipment capability influences the graphical design space for primary drying.

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SP Scientific is the synergistic collection of well-known and highly regarded scientific equipment brands, including VirTis, FTS Systems, Hull, Genevac, Hotpack, and most recently PennTech. The joining of these well-established brands as SP Scientific has created one of the largest and most experienced companies in freeze drying (lyophilization), centrifugal evaporation and concentration, temperature control/thermal management, glassware washers, controlled environments, vial washing and tray loading machines.

More than a scientific equipment supplier, SP Scientific represents brands that distinguish themselves by being able to more thoroughly assist customers in matching equipment to particular application needs. Fortune 500, pharmaceutical, aerospace, automotive, medical device, diagnostic kit and biotechnology companies — as well as government facilities, universities and colleges are among the organizations served on a daily basis.

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LyoLearn Webinars

Webinar Tech Notes

Webinars

Upcoming Sessions

Predictive Models of Lyophilization Process for Development, Scale-up, Technology Transfer, and Manufacturing

Session 1

Session 2

Using Solid-State NMR Spectroscopy as a Tool for Developing Stable Lyophilized Protein Formulations

Session 1

Session 2

Equipment Capability of Freeze Dryers and Its Relevance to the Graphical Design Space for Primary Drying

Session 1

Session 2

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LyoModelling Calculator

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Call us toll free: 800-431-8232 or 845-255-5000

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