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View recent webinars on "Techniques for Enhancing Visualization of Lyophilization Cakes"; the three-part series on "Lyophilization Validation: Operational Qualification and Process Validation"; learn the "Basic Theory of Freeze Drying" and much more...

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LyoLearn Webinars

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Webinars

Free online seminar series with topics of interest to lyophilization scientists and presented by industry experts.

Live sessions allow participants to interact with renowned freeze-drying specialists such as Dr. John Carpenter, Dr. Steve Nail and others in the freeze-drying community.

PLEASE NOTE: You must login before you can register or attend a webinar. Live webinars will be enabled 15 minutes prior to the start of each session.

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Upcoming Sessions

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Impact of Formulation and Processing in Overcoming Long Reconstitution Times of High Concentration Lyophilized Proteins
Date & Time: 4/23/2020 10:00 AM - 3:00 PM ET Presenter(s): Dr. Shreya Kulkarni, Ph.D.
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- Session 1
  
  4/23/2020 10:00 AM - 11:00 AM ET
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- Session 2
  
  4/23/2020 2:00 PM - 3:00 PM ET
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This presentation will provide a fundamental understanding of the factors governing reconstitution times in development of high concentration lyophilized protein formulations. View abstract for more information.

Rapid reconstitution is an important attribute for lyophilized drug products. However, a major challenge to the development of high concentration lyophilized protein formulations is slow and variable reconstitution times, sometimes exceeding 1 hour. The presentation will provide a fundamental understanding of the factors governing reconstitution, particularly focusing on the effects of crystallinity, viscosity and cake porous structure. Strategies for mitigating long reconstitution times by selecting suitable formulation and processing parameters will also be discussed.
Anomalous Behavior of Mannitol Hemihydrate: Implications on Sucrose Crystallization in Colyophilized Systems
Date & Time: 5/20/2020 10:00 AM - 3:00 PM ET Presenter(s): Dr. Seema Thakral, Ph.D.
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- Session 1
  
  5/20/2020 10:00 AM - 11:00 AM ET
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- Session 2
  
  5/20/2020 2:00 PM - 3:00 PM ET
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Mannitol, a popular bulking agent, has propensity to exist in different physical forms in the lyophilized formulations. This webinar will explore dehydration behaviour and dehydration kinetics of mannitol hemihydrate (MHH) and the crystallization propensity of sucrose under relative humidities. View abstract for more information.

Mannitol, a popular bulking agent, has propensity to exist in different physical forms in the lyophilized formulations. Presence of mannitol in its hydrated form is generally undesirable as the released lattice water may cause product degradation and instability. We systematically studied dehydration behaviour of mannitol hemihydrate (MHH) under relative humidities (RH) ranging from 11 to 97% at RT. The dehydration kinetics of MHH and the crystallization propensity of sucrose were simultaneously monitored by X-ray diffractometry (XRD). The dehydration rate increased as a function of water vapor pressure, an anomalous behavior which can be explained by the Smith–Topley effect. Select vials, stored at 40°C, had rubber stoppers fitted with humidity sensors enabling the continuous monitoring the headspace RH. A two-step increase in headspace RH, attributed to MHH dehydration, eventually triggered sucrose crystallization.

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+ Company Overview

SP Scientific is the synergistic collection of well-known and highly regarded scientific equipment brands, including VirTis, FTS Systems, Hull, Genevac, Hotpack, and most recently PennTech. The joining of these well-established brands as SP Scientific has created one of the largest and most experienced companies in freeze drying (lyophilization), centrifugal evaporation and concentration, temperature control/thermal management, glassware washers, controlled environments, vial washing and tray loading machines.

More than a scientific equipment supplier, SP Scientific represents brands that distinguish themselves by being able to more thoroughly assist customers in matching equipment to particular application needs. Fortune 500, pharmaceutical, aerospace, automotive, medical device, diagnostic kit and biotechnology companies — as well as government facilities, universities and colleges are among the organizations served on a daily basis.

SP Scientific is constantly striving for superior service and quality. We want to ensure that our customers become part of our “family” and that we serve each customer to the best of our abilities. Each manufacturing facility is an ISO 9001:2008 rated facility. Industries such as pharmaceutical manufacturing have required that the associates at SP Scientific are well versed in current Good Manufacturing Practices (cGMP), Good Automated Manufacturing Practices (GAMP5), 21CFR, Part 11, electronic signatures and ASME standards.

SP Scientific is a global company with manufacturing facilities in Gardiner and Stone Ridge, New York; Warminster, Pennsylvania; and Ipswich, United Kingdom. Regional sales associates, Distributors and service technicians are located throughout the world. SP Scientific associates and distributors look forward to helping you reach your goals.

SP Scientific is part of SP Industries, Inc. , a leading designer and manufacturer of state-of-the-art laboratory equipment, pharmaceutical manufacturing solutions, laboratory supplies and instruments, and specialty glassware. SP's products support research and production across divers end user markets including pharmaceutical, scientific research, industrial, aeronautic, semiconductor and healthcare. SP's three flagship brands -- SP Scientific, SP Scienceware, and SP Ableware -- represent over 400 combined years of experience, quality, and innovation. In December, 2015, SP Industries was acquired by Harbour Group, a private investment firm founded in 1976. Harbour Group is a privately owned, operations focused company based in St. Louis, Missouri. Headquartered in Warminster, Pennsylvania, SP Industries has production facilities in the USA and Europe and offers a world-wide sales and service network with full product support including training and technical assistance.

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